Circulating Triglycerides Impact on Orexigenic Peptides and Neuronal Activity in Hypothalamus

Circulating triglycerides impact on orexigenic peptides and neuronal activity in hypothalamus.

Little is known about the impact of circulating lipids on brain processes. Building on evidence that chronic fat consumption stimulates hypothalamic peptides in close association with elevated triglycerides (TG), this study examined whether an acute rise in TG levels induced by fat emulsion can affect these hypothalamic systems. In normal weight rats, ip injection of Intralipid (20%, 5 ml) duri...

Increased caloric intake after a high-fat preload: relation to circulating triglycerides and orexigenic peptides.

To investigate mechanisms that mediate the greater food intake induced by a fat-rich diet, the present study tested an acute "preload-to-test meal" paradigm in normal-weight rats. In this paradigm, the rats were given a small high-fat (HF) compared to low-fat (LF) preload and, after an intermeal interval, allowed to consume freely on a subsequent test meal. Modified versions of this paradigm we...

Glucokinase as a Glucose Sensor in Hypothalamus - Regulation by Orexigenic and Anorexigenic Peptides

Impact of diet, physical activity, and alcohol use on triglycerides

A quick biology review might help here: triglycerides are the most common form of fat in the body. Any calories consumed that aren?t burned off are converted into triglycerides. These fats help insulate the body, supply and store energy, and transport fat-soluble vitamins. Here?s where it gets a little complicated: there?s evidence to suggest that when a person has high triglyceride levels in c...

Impact of diet, physical activity, and alcohol use on triglycerides

A quick biology review might help here: triglycerides are the most common form of fat in the body. Any calories consumed that aren?t burned off are converted into triglycerides. These fats help insulate the body, supply and store energy, and transport fat-soluble vitamins. Here?s where it gets a little complicated: there?s evidence to suggest that when a person has high triglyceride levels in c...